Stabilization and structure determination of integral membrane proteins by termini restraining

Shixuan Liu, Shuang Li, Andrzej M. Krezel, Weikai Li

Published: 2022-01-16 DOI: 10.1038/s41596-021-00656-5

integral membrane proteins

stabilization

structure determination

termini restraining

protein coupler

AI 解读

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Heterogeneity（异质性）

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Integral membrane proteins isolated from cellular environment often lose activity and native conformation required for functional analyses and structural studies. Even in their native state, they lack sufficient surfaces to form crystal contacts. Furtherm
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ACKNOWLEDGMENTS

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Stabilization and structure determination of integral membrane proteins by termini restraining

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