Small-animal blood exchange is an emerging approach for systemic aging research

Melod Mehdipour, Payam Amiri, Chao Liu, Jonalyn DeCastro, Cameron Kato, Colin M. Skinner, Michael J. Conboy, Kiana Aran, Irina M. Conboy

Published: 2022-08-18 DOI: 10.1038/s41596-022-00731-5

Small-animal blood exchange

Aging research

Heterochronic parabiosis

Invasive techniques

Mathematical modeling

AI 解读

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We describe a small-animal blood exchange approach developed for aging research as an alternative to heterochronic parabiosis or plasma injections. In parabiosis, animals are surgically coupled, which has several disadvantages, including difficulty contro
Introduction
Materials
Procedure 1: design and fabrication of the small-animal blood exchange device
Procedure 2
Procedure 3: blood exchange mathematical modeling
Troubleshooting
Timing
Anticipated results
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- References
References
ACKNOWLEDGMENTS

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Small-animal blood exchange is an emerging approach for systemic aging research

Extended

Extended Data Fig. 1 Overview and detailed parts and schematics of single-pump small-animal blood exchange device.

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Supplementary Information

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