Interrogation of the mammalian gut–brain axis using LC–MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models

Thomas D. Horvath, Sigmund J. Haidacher, Melinda A. Engevik, Berkley Luck, Wenly Ruan, Faith Ihekweazu, Meghna Bajaj, Kathleen M. Hoch, Numan Oezguen, Jennifer K. Spinler, James Versalovic, Anthony M. Haag

Published: 2022-11-08 DOI: 10.1038/s41596-022-00767-7

organoid cultures

metabolomics

gut-brain axis

LC-MS/MS

gnotobiotic mouse models

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Interest in the communication between the gastrointestinal tract and central nervous system, known as the gut–nobreakbrain axis, has prompted the development of quantitative analytical platforms to analyze microbe- and host-derived signals. This p
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ACKNOWLEDGMENTS

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Interrogation of the mammalian gut–brain axis using LC–MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models

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